Associate Scientist-Receptor pharmacology

·Job Description Summary

We are looking for a PhD with 0-4 years related experience in molecular biology, biochemistry or cell biology field to fill an Associate Scientist-Receptor Pharmacology position in Amgen China R&D Center. The main responsibilities for this position are 1). Receptor expression and purification, 2). GPCR assay development and 3). Characterization of receptor siganling pathway

·Justification

This candidate will work on 1). GPCR assay panel and profiling, 2). receptor expression and purification and 3). characterization of receptor-ligand interaction using biophysical methods

Job Description

Amgen is a leading global biotechnology company with a mission to serve patients around the world. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses. Our medicines have made a dramatic difference in the lives of millions. To underpin our commitment to serve patients in China, Amgen is now establishing a Research and Development facility in Shanghai. Amgen R&D Shanghai Discovery Research laboratory will focus on G protein-coupled receptors (GPCRs), an important class of signaling molecules and potential drug targets. The laboratory is looking for a highly self-motivated and creative scientist to join the Pharmacology Group. The successful candidate will be an integral member of the research team, collaborate with research scientists at multiple Amgen sites, and work closely with teams in other functional areas and local CROs.

Primary responsibilities:

·The candidate is expected to work in a high-matrix environment and drive scientific and technical innovation collaboratively with other members of the group.

·Express and purify receptor for structure biology and antibody discovery

·Develop and validate cell-based, biochemical or biophysical assays (Surface Plasmon Resonance) to support structure biology research and therapeutic discovery efforts

·Understand receptor signaling transduction pathway and compound mechanism of action (MOA) to support drug discovery.

Basic Qualifications

·Ph.D. in molecular biology, cellular biology, biochemistry with 0-4 years of related experience

·Experience in membrane protein expression and purification

·Fluent in reading, writing and speaking English

Preferred Qualifications

·The successful candidate should have a background in receptor pharmacology, principles underlying receptor occupancy and signaling pathway

·Expertise in complex cell-based assays, biochemical and cell signaling approaches, and cell imaging techniques

·Strong scientific knowledge in using biophysical methods to characterize receptor-ligand interaction are highly desired

·Knowledgeable, highly self-motivated, creative, and collaborative.

·Ability to focus on key issues and be result oriented.