深圳湾实验室闫致强课题组招聘联培学生\研究助理\博士后\副研究员

\助理研究员\深圳湾启航学者\合作研究员公告

【深圳湾实验室简介】

深圳湾实验室（生命信息与生物医药广东省实验室，以下简称“实验室”）是广东省、深圳市建设粤港澳国际科技创新中心和综合性国家科学中心的重大战略部署，是深圳建设中国特色社会主义先行示范区行动中，全力支持的重大创新载体。实验室永久场地位于光明科学城，规划总建筑面积40万平方米。

实验室面向世界科技前沿和人民生命健康，紧紧围绕国家战略布局，以协同攻克生命健康重大科学难题为导向，以肿瘤、代谢与心血管、神经退行性、传染性等重大疾病的预防、诊断和治疗为焦点，以IT+BT融合及多学科交叉为特色，开展疾病机理、生命信息、创新药物、医学成像等领域研究。实验室现有十余个研究所/中心，已引进90余支科研团队。

Shenzhen Bay Laboratory, hereinafter referred to as SZBL, is a newly established Guangdong Provincial Laboratory. Located in the heart of Guangdong-Hong Kong-Macau Greater Bay Area, SZBL aspires to be a world-class research institution and intellectual destination dedicated to understanding the fundamental biology underlying health and diseases.

The overarching aim of SZBL is to provide comprehensive and whole-of-life approaches to disease prevention and intervention with bio-inspired technology to explore bioinformatics, biomedicine and medical imaging. Key focuses of research include cancer, cardiovascular and metabolic diseases, neurological and psychiatric disorders, and infectious diseases.

As a burgeoning institution, SZBL has convened more than 90 research groups with transdisciplinary backgrounds and professional expertise to push forward the vision of “Science for Global Health”.

【课题组简介】

课题组组长，闫致强，2004年获复旦大学学士学位。2004-2009年分别于中国科学院神经科学研究所、北京生命科学研究所以及中科院生物物理研究所进行博士研究并获得博士学位。2009-2013加州大学旧金山分校及霍华德·休斯医学研究所师从美国科学院院士詹裕农，叶公杼 (Yuh-Nung Jan，Lily Jan) 进行博士后研究。2014年任复旦大学生命科学学院研究员、博士生导师，获得上海高校特聘教授（东方学者，2014）、上海市青年科技启明星（2014）、2019年升任三级研究员，2020年加入深圳湾实验室分子生理所任资深研究员、副所长。相关研究成果以第一/通讯作者(含共同)在Nature, Neuron, Nature Structural & Molecular Biology, PNAS, Nature Communications, eLife, Cell Reports等国际高水平杂志发表多篇论文。获4项国家科技部重大研究计划、2项国家自然科学基金委面上项目支持。

Dr. Zhiqiang Yan obtained his bachelors degree from Fudan University in 2004, Then, he pursued his Ph.D. degree in Neurobiology, Institute of Neuroscience, Chinese Academy of Sciences, National Institute of Biology Sciences, Beijing & Institute of Biophysics, Chinese Academy of Sciences form 2004-2009. He received postdoctoral training in both Lily Jan’ group and Yuh Nung Jan group at Howard Hughes Medical Institute &University of California at San Francisco, San Francisco, USA. In 2014, he was appointed as a professor in Fudan University. Then, he joined Shenzhen Bay Laboratory as a senior principal investigator at 2020 and appointed as deputy director at 2022. He has won honors such as Human Frontier Science Program (HFSP) Long-term Fellowship(2010), Shanghai Youth Science and Technology Venus (2014), The Shanghai Rising-Star Program (2014), etc. Dr. Yan has published papers as first or corresponding author (including co-authors) in journals including Nature, Neuron, Nature Structural & Molecular Biology, PNAS, Nature Communications, eLife, Cell Reports, etc. He was supported by 4 National Key Research and Development Projects of China and 2 general programs of the National Natural Science Foundation of China.

课题组研究方向：

长期致力于感觉神经生物学，综合运用分子生物学、蛋白相互作用和结构分析，电生理记录、神经回路的光遗传、化学遗传和成像等技术手段，结合药物筛选和基因编辑小鼠模型，研究听觉、触觉等感觉受体的鉴定和工作机制研究，感觉系统神经回路，以及感觉系统疾病的机理和治疗。

1. 听觉、触觉、湿度感觉、渴觉等感觉受体的鉴定、其装配和工作机制研究。

2. 感觉系统神经回路的功能研究：

鉴定在触觉、痛觉、平衡觉、听觉、渴觉、内脏感觉等的关键神经细胞群和神经回路，研究其发挥生理功能的机制，以及其和其他重要生理功能的交互作用。

3. 感觉系统疾病的机理和治疗：

研究遗传性耳聋的的致病机理、诊断以及基因和药物治疗，耳鸣等神经活动异常疾病的神经回路机制，结合本实验室在离子通道功能分析和药物筛选的技术优势，开发其治疗方法。

Research direction：

We study sensory neurobiology, identify the receptors and neural circuits for sensation and interoception, study their working mechanism and related the diseases in sensory system.

1. Identify the receptors for hearing, touch, pain and thirst sensation, and study the gating and assembly of the related sensory transduction complex.

2. Map the critical neuronal groups and circuits for sensation and interoception such as touch, pain, vestibular and thirst sensation, study their function in various physiological processes.

3. Study pathogenic mechanism, diagnosis and treatment of congenital hearing loss, the cellular and circuitry basis of tinnitus, based on our expertise on function assay of ion channel to develop related drugs.

因课题组科研工作需要，诚招神经生物学、分子生物学与生物化学、生理学、细胞生物学、结构生物学、药物化学等生物医学研究相关专业背景的人员，实验室十分欢迎多学科专业融合发展。

We are looking for aspiring young people with professional backgrounds in neurobiology, molecular biology and biochemistry, cell biology, structural biology, pharmaceutical chemistry, etc. are sincerely invited. The laboratory welcomes the integration and development of multi-disciplinary specialties.

【招聘岗位介绍】

1. 博士后（Postdoctoral Researcher）

在课题组组长指导下开展科研工作，同时欢迎优秀博士后自带课题加入课题组开展合作；支持其申请国家自然科学基金及省、市各级项目，年薪30-50万。

Carry out scientific research under the guidance of the leader of the research group, and welcome outstanding postdoctoral researchers to bring their own topics to the research group for cooperation; Support its application for National Natural Science Foundation of China and projects at provincial and municipal levels.300000-500000 yuan per year.

博士后可根据自身博士研究方向从事对应的研究方向：

神经生物学研究方向：感觉受体和感觉神经回路的鉴定及功能研究

分子生物学与生物化学、细胞生物学研究方向：以TMC为核心的听觉转导复合物的组分鉴定和组装机制研究

结构生物学研究方向：感觉受体离子通道及其复合物包括TMC，TMEM63的结构、离子通透性和门控机制分析

生理学研究方向：新型离子通道TMEM63家族，TMC家族1-8的生理功能分析

药物化学研究方向：感觉系统疾病包括耳鸣、遗传性耳聋等的治疗和药物开发

2. 副研究员/助理研究员（Associate Research Fellow/Assistant Research Fellow）

在课题组组长指导下开展科研工作，同时欢迎自带课题加入课题组开展合作；支持其申请国家自然科学基金及省、市各级项目，年薪30-50万。

Carry out scientific research under the guidance of the leader of the research group, and welcome researchers to bring their own topics to the research group for cooperation; Support its application for National Natural Science Foundation of China and projects at provincial and municipal levels.300000-500000 yuan per year.

助理研究员、副研究员可根据自身博士研究方向和工作研究背景从事以下研究方向：

神经生物学研究方向：感觉受体和感觉神经回路的鉴定及功能研究

分子生物学与生物化学、细胞生物学研究方向：以TMC为核心的听觉转导复合物的组分鉴定和组装机制研究

结构生物学研究方向：感觉受体离子通道及其复合物包括TMC，TMEM63的结构、离子通透性和门控机制分析

生理学研究方向：新型离子通道TMEM63家族，TMC家族1-8的生理功能分析

药物化学研究方向：感觉系统疾病包括耳鸣、遗传性耳聋等的治疗和药物开发

3. 联培学生/实习生 （Intern）

学习进行分子克隆、细胞培养、膜片钳电生理以及小鼠的行为分析、药物递送和脑部成像等实验，或进行自己感兴趣的自由科研探索。

实习期间补贴生活费，优秀者可以进入香港大学、香港科技大学、首都医科大学、西班牙巴塞罗那IDIBELL研究所、南方科技大学、华南理工大学等与深圳湾实验室联合项目的高校进行博士，硕士研究，或成为深圳湾实验室全职员工。

Learn experimental skills such as molecular cloning, cell culture, patch-clamp electrophysiology, and behavioral analysis of mice, drug delivery, and brain imaging, or other topics you are interested in.

During the internship, the living expenses will be subsidized, and outstanding students can be recommended go to the University of Hong Kong, Hong Kong University of Science and Technology, Capital Medical University, Southern University of Science and Technology, South China University of Technology and other universities that have joint projects with Shenzhen Bay Laboratory for doctoral and master’s research, or become Shenzhen Bay Laboratory full-time Employee.

深圳湾实验室2022年与香港高校联合培养博士研究生招生简章：https://www.szbl.ac.cn/careers/upcomingevents/2197.html

深圳湾实验室与西班牙巴塞罗那IDIBELL研究所招生简章：https://www.szbl.ac.cn/careers/upcomingevents/2404.html

4. 研究助理（Research Assistant）

完成课题组组长安排的实验任务，研究助理表现优秀者可推荐攻读实验室联合培养的硕士、博士项目，颁发联培院校证书。

Aim to complete the experimental tasks assigned by the group leader. If you perform well, You can be recommended to study for a masters or doctoral degree in a joint training school.

5. 深圳湾启航学者（Shenzhen Bay Fellow）

深圳湾启航学者是全职岗位，旨在培养和支持一批学术基础扎实、具有突出创新能力和发展潜力且处于职业生涯早期的青年学者，强化实验室各研究所/中心学术梯队和科研团队的建设，鼓励大胆的原创科研探索。“深圳湾学者”实行聘期制，聘期为3年。聘期届满且考核优秀者，可申请实验室特聘研究员（Junior Principal Investigator）岗位https://www.szbl.ac.cn/careers/recruitmentnotice/285.html.

Shenzhen Bay Fellow is a full-time position, offering talented and promising early-career-researchers the opportunity to start their own independent research in a nurturing and multidisciplinary environment at SZBL. The employment term is three years in general. After a Shenzhen Bay Fellow’s term is completed, fellows are encourged to apply for the Junior Principal Investigator position based on their work performance, and the relevant recruitment ad for Junior Principal Investigator position could be found at

https://www.szbl.ac.cn/careers/recruitmentnotice/285.html.

6. 国内合作研究员/访问学者

具有博士学位，在国内高校及科研机构中从事生命科学领域前沿研究的教职员工，有相应的研究成果和论文发表等，且与本实验室有强烈的合作意向，可由原单位外派脱产到深圳湾实验室进行2年以上的合作科学研究。

Faculty and staff with doctoral degrees who are engaged in cutting-edge research in the field of life sciences in domestic universities and institutions, with relevant research work has been published, and have a strong intention to cooperate with our lab, and also can be dispatched to Shenzhen Bay laboratory by the original unit to conducts collaborative scientific research for more than 2 years.

（1）合作开展科学研究工作；

（2）合作申请各项科学研究项目和基金。

Cooperation in scientific research. Cooperative application for various internal and external (including national and regional) research projects and grants。

【福利待遇】

（1）提供具有国际竞争力的薪酬待遇（博士后、助理研究员、副研究员年薪30-50万），提供可持续发展的职业规划；

（2）提供良好的科研工作环境，尖端的技术支撑平台；

（3）协助申请国家级、地方级人才项目和人才奖励；

（4）协助外籍员工办理工作许可、办理居留许可、申请个税优惠；

（5）其它福利待遇，包括提供五险一金、补充医疗保险、年度健康体检、带薪年假、人才住房；接收户口档案；协助子女入学等。

Qualified candidates will receive an internationally competitive salary, state-of-the-art core facilities. Assistance will be provided in applying for national and regional talent awards and subsides. Other benefits provided by SZBL include insurance and housing fund, supplementary medical insurance, annual physical examination, paid annual leave, public rental housing, and children’s education. For international staff, we also help them to apply for work permit, residence permit and foreign tax preference.

【应聘方法】

应聘者请提供以下PDF版材料：

（1）自荐信

（2）个人简历及代表性科研成果

（3）科研计划

（4）其它能够证明科研能力的材料

（1）Cover letter;

（2）Curriculum vitae, including lists of publications and research funding;

（3）Research summary and research plan;

（4）Other materials that can prove scientific research ability

请应聘者将上述材料，统一成PDF文件发送至：zqyan@szbl.ac.cn（闫致强）并抄送fanghy@szbl.ac.cn（邮件主题：姓名+应聘职位）。

咨询联系人：方老师 电话：0755-26849230 邮箱：fanghy@szbl.ac.cn

2022年深圳湾实验室招聘公告