日本东京大学Teruhiro Okuyama课题组取得一项新突破。他们的研究开发出了社会记忆中效价更新的神经回路。相关论文于2026年7月9日发表在《科学》杂志上。

通过人为地将先前中性的同侧特异性转化为攻击性的同侧特异性，研究组发现价态更新依赖于海马腹侧CA1 (vCA1) -基底外侧杏仁核(BLA) -伏隔核（NAc）回路中突触连通性的增强和生理变化。失败后，vCA1的社会记忆印迹神经元加强了与携带负价的BLA神经元的联系。vCA1-BLA-NAc神经回路灵活调节适应性社会行为。

据了解，群居动物能识别熟悉的同类，并选择性地避开有害的同类。随着社会关系的转变，社会效价的持续更新是必不可少的，但其潜在的神经机制尚不清楚。

附：英文原文

Title: Neural circuits for valence updating in social memory

Author: Narutoshi Suto, Mu-Yun Wang, Shota Morikawa, Myung Chung, Kentaro Tao, Ziyan Huang, Yuji Ikegaya, Haruki Takeuchi, Shinichiro Kira, Teruhiro Okuyama

Issue&Volume: 2026-07-09

Abstract: Social animals recognize familiar conspecifics and selectively avoid harmful ones. As social relationships shift, continuous updating of social valence is essential, yet the underlying neural mechanisms remain unclear. Here, by artificially transforming a previously neutral conspecific into an aggressive one, we show that valence updating depends on enhanced synaptic connectivity and physiological changes within the hippocampal ventral CA1 (vCA1)–basolateral amygdala (BLA)–nucleus accumbens (NAc) circuit. Following defeat, social memory engram neurons in the vCA1 strengthened their connections with BLA neurons carrying negative valence. The vCA1–BLA–NAc neural circuit flexibly regulates adaptive social behaviors.

DOI: adx8231

Source: https://www.science.org/doi/10.1126/science.adx8231

期刊信息

Science：《科学》，创刊于1880年。隶属于美国科学促进会，最新IF：63.714

官方网址：https://www.sciencemag.org/

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