中国农业大学生物学院教授魏育蕾与中国科学院动物研究所研究员于乐谦联合团队的研究显示，通过胚胎外细胞协调重建人类原始条纹形成。该研究于2026年6月24日发表于国际一流学术期刊《细胞》杂志上。

该研究组开发了一个明确的共培养系统，其中胚胎干细胞（ESCs）与各种胚胎外细胞类型一起培养，模拟体内羊膜外胚层、滋养层和胚胎外中胚层，并揭示了不同胚胎外细胞在调节胚胎细胞中的作用。

此外，利用微工程技术的优势，研究团队在空间和分子上重构了不同胚胎外细胞和胚胎细胞之间的相互作用，证明胚胎外细胞单独协调调节可以再现人类原始条纹（PS）的形成，同时也表现出扩展的发育潜力。这一进展可能允许实验探索和操作以前无法进入的人类早期原肠胚形成阶段，为瞥见这一关键发育过程的开始提供机会。

据介绍，原肠胚形成是人类发育的基本阶段，由胚胎和胚胎外组织之间的忠实相互作用所支配。尽管其重要性，胚胎外谱系在指导胚胎多样化和组织中的作用仍然是未知的。

附：英文原文

Title: Reconstituting human primitive streak formation through extra-embryonic cell coordination

Author: Qiaoyan Shen, Xin Zhang, Naixin Chen, Xiaodi Yan, Hongan Ren, Xizhuang Sun, Linjie Xu, Jianchao Zhao, Rong Li, Sirui Lin, Xiaojie Jia, Leqian Yu, Yulei Wei

Issue&Volume: 2026-06-24

Abstract: Gastrulation is the fundamental stage of human development, governed by the faithful interaction between embryonic and extra-embryonic tissues. Despite its significance, the role of extra-embryonic lineages in directing embryonic diversification and organization remains elusive. Here, we developed a defined co-culture system where embryonic stem cells (ESCs) are cultured with various extra-embryonic cell types, mimicking in vivo amniotic ectoderm, trophoblast, and extra-embryonic mesoderm, and uncovered the previously unrecognized role of different extra-embryonic cells in regulating embryonic cells. Furthermore, leveraging the advantages of microengineering techniques, we spatially and molecularly reconstructed the interactions among distinct extra-embryonic and embryonic cells, demonstrating that the coordinated regulation of extra-embryonic cells alone can recapitulate the human primitive streak (PS) formation, while also exhibiting extended developmental potential. This advancement may allow for experimental exploration and manipulation of previously inaccessible stages of human early gastrulation, providing an opportunity to glimpse the onset of this crucial developmental process.

DOI: 10.1016/j.cell.2026.05.045

Source: https://www.cell.com/cell/abstract/S0092-8674(26)00645-8